Diagnostic value of D‐dimers for limb deep vein thrombosis in children: A prospective study

Abstract The present study sought to evaluate the discriminative and predictive ability of D‐dimer for pediatric limb DVT. Children aged 28 days–18 years requiring imaging rule out DVT, as per treating clinical team, were enrolled in study. outcome was ultrasound proven levels obtained around time imaging. Receiver operating characteristic (ROC) curves logistic regression models used data analyses. In total, 296 patients between 2017–2020; 204 diagnosed with DVT (DVT[+]). Median 2.3 μg/ml FEU (25th–75th percentile 0.9–3.9) among DVT(+) 1.9 0.8–4.0) DVT(−) ( p = 0.60). area under ROC curve (AUC) 0.52 (95% confidence interval [CI] 0.45–0.59). odds ratio 1.00 CI 0.99–1.01), holding confounders constant. a sub‐group exploratory analysis including 23 no underlying conditions or co‐morbidities, AUC 0.90 0.76–1.00). conclusion, this prospective cohort consecutive children suspected had poor However, showed better an sample co‐morbidities at diagnosis.